BioinformaticsbioRxivPreprint
Pathway impact analysis (PIS) for robust and comprehensive interpretation of differentially expressed genes (DEGs)
Yeogha Yoon, Minji An, Hanbi Lee, Wankyu Kim
The paper introduces PIS, a method to improve DEG selection by optimizing thresholds for pathway enrichment, showing better recovery of true DEGs and stability across datasets.
DOI 10.1101/2025.09.08.674792