Heterogeneous complement and microglia activation mediates stress-induced synapse loss
Breeanne M. Soteros, Haven Tillmon, Mackenna Wollet, Julianne General, Hanna Chin, John Beichen Lee, Flavia Regina Carreno, David A. Morilak, Jun Hee Kim, Gek-Ming Sia
This study shows that stress-induced synapse loss in the mouse medial prefrontal cortex is mediated by heterogeneous complement activation and microglia states, with ApoEhigh microglia contributing to layer-specific synapse loss.
bioRxiv · Jun 28, 2023 · PreprintNeuroscience