NeurosciencebioRxivPreprint
Heterogeneous complement and microglia activation mediates stress-induced synapse loss
Breeanne M. Soteros, Haven Tillmon, Mackenna Wollet…·Gek-Ming Sia
This study shows that stress-induced synapse loss in the mouse medial prefrontal cortex is mediated by heterogeneous complement activation and microglia states, with ApoEhigh microglia contributing to layer-specific synapse loss.
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