The temperature dependence of binding entropy is a selective pressure in protein evolution
Rosemary Georgelin, Hannah Bott, Joe A. Kaczmarski, Rebecca L. Frkic, Li Lynn Tan, Nobuhiko Tokuriki, Matthew A. Spence, Colin J. Jackson
The paper examines how thermodynamic binding strategies in proteins evolved in response to temperature changes, showing a shift from entropy-driven to enthalpy-driven binding over time.
bioRxiv · Mar 23, 2025 · PreprintBiochemistry