An Unusual Follower Peptide is Required for Biosynthesis of the Antibiotic Lasso Peptide Triculamin
Tiziana Svenningsen, Aske Merrild, Asger Buchbjerg Petersen, Aliana Nosolini Dos Reis, Anne Mette Pold, Hannah H. Lange, Thomas Tørring
This study identifies an essential follower peptide for triculamin biosynthesis and shows its role in enzyme-substrate complex formation and substrate promiscuity.
The Journal of Antibiotics · Oct 26, 2026Peer-reviewedSynthetic Biology