The SARSCoV2 spike protein alters barrier function in 2D static and 3D microfluidic in vitro models of the human blood-brain barrier
Tetyana P. Buzhdygan, Brandon J. DeOre, Abigail Baldwin‐Leclair, Trent A. Bullock, Hannah M. McGary, Jana A. Khan, Roshanak Razmpour, Jonathan F. Hale, Peter A. Galie, Raghava Potula, Allison Michelle Andrews, Servio H. Ramirez
This study investigates how SARS-CoV-2 spike protein affects the blood-brain barrier using in vitro models, showing barrier disruption and pro-inflammatory responses in human brain endothelial cells.
Neurobiology of Disease · Oct 11, 2020Peer-reviewedNeuroscience