A human ex vivo model of radiation-induced skin injury reveals p53-driven DNA damage signaling and recapitulates a TGFβ fibrotic response
Caroline Dodson, Sophie M. Bilik, Gabrielle DiBartolomeo, Hannah Pachalis, Lindsey G. Siegfried, Jordan A.K. Johnson, Seth Ray Thaller, Irena Pastar, Marjana Tomic‐Canic, Anthony J. Griswold, Rivka C. Stone
This study develops a human ex vivo skin model that recapitulates radiation-induced DNA damage and fibrotic responses, identifying p53-driven pathways and potential therapeutic targets.
bioRxiv · Jun 4, 2025 · PreprintGenomics