Marjana Tomic‐Canic

Multi-omics identification of activated T cells and spatial PD-1/PD-L1 signaling as biomarkers of diabetic foot ulcer healing

The paper identifies T cell activation and PD-1/PD-L1 signaling as biomarkers for diabetic foot ulcer healing using multi-omics approaches across multiple cohorts.

NDR1/2 kinases regulate cell polarization and cell motility through Cdc42 GTPase and Pard3 signaling in mammalian cells

This study shows NDR1/2 kinases regulate cell polarization and motility via Cdc42 and Pard3 signaling in human fibroblasts, affecting wound healing.

A human ex vivo model of radiation-induced skin injury reveals p53-driven DNA damage signaling and recapitulates a TGFβ fibrotic response

This study develops a human ex vivo skin model that recapitulates radiation-induced DNA damage and fibrotic responses, identifying p53-driven pathways and potential therapeutic targets.

Integrative small and long RNA-omics analysis of human healing and non-healing wounds discovers cooperating microRNAs as therapeutic targets

The paper identifies 17 microRNAs involved in chronic wound healing through integrative RNA-omics analysis and suggests they as therapeutic targets.