Metabolomic, lipidomic, and N-glycomic analyses of a human cell model of Krabbe disease reveal treatable deficits in glycosylation and serine-ceramide metabolism
Rodrigo T. Starosta, Hannah Saeger, Johanna ten Hoeve, S.J. Kim, Johan L.K. Van Hove, Xuntian Jiang, Miao He, Neal K. Bennett
The paper identifies metabolic deficits in a Krabbe disease model, including enhanced ceramide synthesis and disrupted glycosylation, suggesting new therapeutic targets.
bioRxiv · Aug 17, 2026 · PreprintSystems Biology