Author

Neal K. Bennett

Gladstone InstitutesORCID 0000-0003-3120-4164Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Assay:CRISPR screen· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Ken NakamuraiD· 3 shared Isha H. JainiD· 2 shared Megan LeeiD· 2 shared Will FlaniganiD· 2 shared Adam L. OrriD· 1 shared Alan H. BaikiD· 1 shared Alexander R. PicoiD· 1 shared Ayush D. MidhaiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersSystems Biology

Ken NakamuraORCID

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4 papers

Recent·Most cited

Systems BiologybioRxivPreprintAug 17, 2026

Metabolomic, lipidomic, and N-glycomic analyses of a human cell model of Krabbe disease reveal treatable deficits in glycosylation and serine-ceramide metabolism

Rodrigo T. Starosta, Hannah Saeger, Johanna ten Hoeve…·Neal K. Bennett

The paper identifies metabolic deficits in a Krabbe disease model, including enhanced ceramide synthesis and disrupted glycosylation, suggesting new therapeutic targets.

DOI 10.64898/2026.08.12.744295

humanmetabolomics

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Cell BiologybioRxivPreprintJan 27, 2026

Genome-wide CRISPRi screen identifies basigin loss as protective in cardiac hypoxia

Will Flanigan, Ayush D. Midha, Skyler Y. Blume…·Isha H. Jain

The paper uses a CRISPRi screen to identify basigin loss as protective in cardiac hypoxia by enhancing ATP maintenance and survival.

2 citations

humangenetic perturbation / CRISPR

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Systems BiologybioRxivPreprintDec 19, 2025

Genetic regulators of neuronal survival across metabolic environments

Neal K. Bennett, Yanilka Soto-Muniz, Jonathan Xianglong Meng…·Ken Nakamura

The paper identifies genetic regulators of neuronal survival across different metabolic environments using CRISPRi screens in human neurons.

DOI 10.64898/2025.12.19.695350

humanCRISPR screen

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Systems BiologyProceedings of the National Academy of SciencesPeer-reviewedJan 11, 2024

Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production

Neal K. Bennett, Megan Lee, Adam L. Orr, Ken Nakamura

The paper uses CRISPRi and FACS to compare effects of respiratory gene knockdown on ROS and ATP, identifying differential regulators of these processes.

31 citationstop 4%

humanCRISPR screen

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