Stochastic survival of the densest and mitochondrial DNA clonal expansion in ageing
Ferdinando Insalata, Hanne Hoitzing, Juvid Aryaman, Nick S. Jones
This paper presents a spatial model showing that mitochondrial DNA mutations expand through stochastic survival of the densest and noise, not replicative advantage, explaining ageing-related clonal expansion.
bioRxiv · Sep 1, 2020 · PreprintGenetics