Mechanisms mediating arylidene-indolinones induced degradation: thoughts on "Discovery of a Drug-like, Natural Product-Inspired, DCAF11 Ligand Chemotype"
Chao Zhong, Ziying Wang, Zhaoyang Li, Haofeng Li, Qianhui Xu, Wanli Wu, Cong Liu, Yiyan Fei, Yu Ding, Boxun Lu
The paper discusses discrepancies in conclusions about arylidene-indolinones' mechanism of action, suggesting possible explanations for conflicting findings on their role as DCAF11 ligands and autophagy-tethering compounds.
bioRxiv · Mar 5, 2024 · PreprintBiochemistry