Boxun Lu

Autophagosome-tethering compounds selectively lower mutant ataxin-3 in preclinical models of spinocerebellar ataxia type 3

Small-molecule autophagosome-tethering compounds selectively lower mutant ataxin-3 through an LC3- and autophagy-dependent mechanism and improve disease-related phenotypes in preclinical models of SCA3.

Post-translational modifications orchestrate the intrinsic signaling bias of orphan receptor GPR52

This study identifies how N-glycosylation and phosphorylation in specific motifs of GPR52 differentially regulate its signaling bias and cellular function.

Modulating glial genes involved in synaptic function mitigates pathogenesis and behavioral deficits in a Drosophila model of Huntington's Disease

The paper shows that reducing glial genes involved in synaptic function reduces disease pathology and behavioral issues in a Drosophila Huntington's Disease model.

Tau Accumulation via Reduced BAG3-mediated Autophagy Is Required for GGGGCC Repeat Expansion-Induced Neurodegeneration

This study shows that reduced BAG3-mediated autophagy leads to tau accumulation, contributing to neurodegeneration in Drosophila models of CAG and GGGGCC repeat expansions.