Inhibition of CGRP receptor ameliorates AD pathology by reprogramming lipid metabolism through HDAC11/LXRβ/ABCA1 signaling
Guangchun Fan, Fangzheng Chen, Min Liang, Ping Yang, Hongtian Dong, Jing Su, Mengqi Wang, Ziyuan Wang, Penggang Ning, Chenye Shen, Xiwen Tang, Xin Yan, Haoxiang Lin, Jiayin Zhao, Yunhe Zhang, , Fang Huang
This study shows that inhibiting the CGRP receptor reduces AD pathology by reprogramming lipid metabolism via the HDAC11/LXRβ/ABCA1 signaling pathway in both human and mouse models.
bioRxiv · Oct 17, 2025 · PreprintNeuroscience