Author

Harm Brugge

University Medical Center Groningen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetics· 3 Genomics· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Approach:statistical model· 5 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:deconvolution· 1 Research Focus:eQTL / molecular QTL mapping· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Dylan H. de VriesiD· 4 shared Lude FrankeiD· 4 shared Monique G.P. van der WijstiD· 4 shared Morris A. SwertziD· 4 shared Patrick DeeleniD· 4 shared Roy OeleniD· 3 shared Annique ClaringbouldiD· 2 shared Cisca WijmengaiD· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersGenomics

Dylan H. de VriesORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

Urmo Võsa, Annique Claringbould, Harm-Jan Westra, Marc Jan Bonder, Patrick Deelen, Biao Zeng, Holger Kirsten, Ashis Saha, Roman Kreuzhuber, Seyhan Yazar, Harm Brugge, Roy Oelen, Dylan H. de Vries, Monique G.P. van der Wijst, Silva Kasela, , Bruce M. Psaty

The paper uses blood eQTL meta-analysis to explore the polygenic architecture of complex traits, finding that trans-eQTLs are more informative for identifying causal genes than cis-eQTLs.

Nature Genetics · Sep 1, 2021Peer-reviewedGenomics

Single-cell RNA-sequencing reveals widespread personalized, context-specific gene expression regulation in immune cells.

Roy Oelen, Dylan H. de Vries, Harm Brugge, Gracie Gordon, Martijn Vochteloo, Chun Ye, Harm-Jan Westra, Lude Franke, Monique G.P. van der Wijst

The paper uses single-cell RNA-sequencing to show that gene expression in immune cells is influenced by genetic variation and pathogen exposure, revealing context-specific regulatory mechanisms.

bioRxiv · Jun 4, 2021 · PreprintGenetics

Deconvolution of bulk blood eQTL effects into immune cell subpopulations

Raúl Aguirre‐Gamboa, Niek de Klein, Jennifer Di Tommaso, Annique Claringbould, Monique G.P. van der Wijst, Dylan H. de Vries, Harm Brugge, Roy Oelen, Urmo Võsa, Maria Magdalena Zorro, Xiaojing Chu, Olivier B. Bakker, Zuzanna Borek, Isis Ricaño-Ponce, Patrick Deelen, , Yang Li

The paper introduces Decon2, a method to deconvolute bulk blood eQTL effects into immune cell subpopulations, showing high concordance with experimental and single-cell studies.

BMC Bioinformatics · Jun 12, 2020Peer-reviewedGenomics

Improving the diagnostic yield of exome-sequencing, by predicting gene-phenotype associations using large-scale gene expression analysis

Patrick Deelen, Sipko van Dam, Johanna C. Herkert, Juha M Karjalainen, Harm Brugge, Kristin M. Abbott, Cleo C. van Diemen, Paul A. van der Zwaag, Erica H. Gerkes, Evelien Zonneveld‐Huijssoon, Jelkje J. de Boer-Bergsma, Pytrik Folkertsma, Tessa E. Gillett, K. Joeri van der Velde, Roan Kanninga, , Lude Franke

This paper introduces GADO, a tool that uses gene expression data to predict gene-phenotype associations and improve diagnostic yield in exome sequencing by prioritizing variants in patients with unknown genetic diagnoses.

Nature Communications · Jun 28, 2019Peer-reviewedGenetics

Single-cell RNA sequencing reveals cell-type specific cis-eQTLs in peripheral blood mononuclear cells

LifeLines Cohort Study, Monique G.P. van der Wijst, Harm Brugge, Dylan H. de Vries, Patrick Deelen, Morris A. Swertz, Lude Franke

The paper uses single-cell RNA sequencing to identify cell-type specific cis-eQTLs in peripheral blood mononuclear cells and validates them against whole blood RNA-seq data.

Nature Genetics · Mar 29, 2018Peer-reviewedGenetics