HOTAIR primes the Ewing sarcoma family of tumors for tumorigenesis via epigenetic dysregulation involving LSD1
Hasan Siddiqui, Julia Selich-Anderson, Joshua Felgenhauer, James Fitch, Vijay Nadella, Cenny Taslim, Laura Tomino, Emily Theisen, Satoru Otsuru, Edwin Horwitz, Stephen Lessnick, Peter White, Nilay Shah
This study shows HOTAIR supports Ewing sarcoma tumor growth by altering epigenetic regulation through interaction with LSD1, enabling cell survival despite EWS-FLI1 toxicity.
bioRxiv · Jan 8, 2018 · PreprintCancer Biology