The small GTPase Rem2 modulates sex-dependent spatial learning by regulating CA1 glutamate receptor composition
William E. Brew, Hassan E. Mohammed, Afrina Asad Meghla, Serendipity Coniglio, Eleanor Labriola, Regan Skudlarek, Kishore Kumar S. Narasimhan, Shashank Manohar Dravid, Gillian Queisser, Anna R. Moore, Victor M. Luna
This study shows that Rem2 deletion improves spatial learning in female mice by altering glutamate receptor composition, revealing a role for Rem2 in sex-dependent learning differences.
bioRxiv · Sep 22, 2026 · PreprintNeuroscience