Victor M. Luna

The small GTPase Rem2 modulates sex-dependent spatial learning by regulating CA1 glutamate receptor composition

This study shows that Rem2 deletion improves spatial learning in female mice by altering glutamate receptor composition, revealing a role for Rem2 in sex-dependent learning differences.

Effects of electroconvulsive shock on the function, circuitry, and transcriptome of dentate gyrus granule neurons

This study shows ECS-induced neurogenesis is necessary for antidepressant effects and identifies transcriptomic changes in granule neurons.

Novel, small molecules targeting the 5-HT4R receptor protect against stress-induced maladapative behavior with efficacy across age

The paper develops and tests novel 5-HT4R-targeting compounds that reduce stress-induced maladaptive behaviors in mice, showing efficacy across age groups.

A tale of two receptors: simultaneous targeting of NMDARs and 5-HT4Rs exerts additive effects against stress

This study investigates the combined effects of (R,S)-ketamine and prucalopride on stress-induced behaviors and neural activity, finding additive benefits in reducing fear, despair, and hyponeophagia.

Adult born hippocampal granule cells promote pattern separation by bidirectionally modulating the remapping of place and cue cells.

This study investigates how adult born granule cells influence pattern separation by modulating remapping of place and cue cells in the hippocampus.

Prophylactic efficacy of 5-HT4R agonists against stress

This study tests if 5-HT4R agonists can prevent stress-induced behaviors in mice, finding that some are effective as prophylactics.