Sickle cell status skews malaria parasite genotype at infection
Helena D. Hopson, Alejandra Herbert-Mainero, Aline Gaëlle Bouopda-Tuedom, Charlène Tina Nanssong-Vomo, Brigitte Tumamo Fotso, Belinda Claire Kiam, Ibrahima Ibrahima, Clément Janvier Onguene, Luc Abate, Radoslaw Igor Omelianczyk, Heather D. Evans, Lyra E. Horton, Gavin Band, Tracey J. Lamb, Lawrence S. Ayong, , Ellen Miranda Leffler
The paper shows that HbS carriers have parasites with Pfsa+ alleles, suggesting these alleles may reduce symptomatic malaria in HbS carriers.
bioRxiv · Sep 9, 2025 · PreprintGenetics