Gavin Band

This paper introduces scTAPAS, a method to reconstruct donor genotypes from scRNA-seq data, enabling eQTL and HLA-TCR analysis without conventional genotyping.

The paper identifies African-specific genetic loci associated with iron status and risk of severe malaria and bacteremia in children, highlighting limited transferability of European polygenic risk scores.

The paper shows that HbS carriers have parasites with Pfsa+ alleles, suggesting these alleles may reduce symptomatic malaria in HbS carriers.

The paper investigates how geographical variation influences the adaptive evolution of Plasmodium falciparum mutations that counteract sickle cell trait protection.

The paper identifies a novel genetic locus OSBPL11 associated with vitamin D levels and cardiometabolic health in African populations through genome-wide analysis.

This paper introduces HLA-colocalization, a method for genetic colocalization at the HLA locus using HLA alleles, showing it identifies novel causal associations between viruses and autoimmune diseases.

The paper genotypes PIEZO1 STR alleles in malaria cases and controls, finding a modest protective effect of E756del against malaria.

The paper investigates how non-O ABO blood group genotypes relate to Plasmodium falciparum rosetting and severe malaria risk in Kenyan children.

The paper investigates the association between host sickle cell haemoglobin and parasite genetic variation in malaria severity, finding that parasite alleles linked to HbS show strong linkage disequilibrium and frequency covariation with HbS.

The paper uses long-read sequencing and de novo assembly to identify structural variation in immune system gene regions from a single individual, revealing challenges in current variant calling methods.

This study examines the genetic structure of Ethiopians, linking cultural and geographic factors to genetic diversity and intermixing across 68 ethnic groups.

This study identifies five genome-wide associations with severe malaria risk in 17,000 individuals from Africa, Asia, and Oceania, including a new variant linked to cerebral malaria.

This paper introduces a Bayesian framework for meta-analyzing GWAS across diverse phenotypes, showing increased power compared to frequentist methods.

This study identifies 114 genome-wide significant loci for schizophrenia and bipolar disorder, with specific subphenotype associations and four genes distinguishing the disorders.

Encoding imputed genotype probabilities at 8 bits in BGEN gave compact files, ~240 million probabilities parsed per second and association results near-identical to 20-bit data (UK BiLEVE chromosome 22).

The paper identifies ancestry deviation regions in sub-Saharan African populations to infer recent adaptive gene-flow contributing to traits like lactose persistence and malaria resistance.

Quality-controlled genotypes for 488,377 UK Biobank participants at 805,426 markers, imputed to ~96 million variants, plus ancestry PCs, kinship (30.3% have close relatives enrolled) and HLA calls.

The paper identifies a structural variant in GYPA and GYPB genes associated with reduced risk of severe malaria in sub-Saharan African populations.

This study analyzes admixture patterns in 48 African populations, revealing recent gene flow and shared ancestry due to historical migrations and agricultural expansions.