RNA self-association limits the removal of double-stranded RNA by affinity chromatography
Nathaniel E. Clark, Heather Mallory, Christian J Ndong, Matthew R. Schraut, Roger A. Winters, Jennifer Freise, Brandon L. Kier, Matthew J. Ranaghan, Lisa Deprez, Senne Dillen, Kelley Kearns, Jing Zhu, Thomas C. Scanlon
This study evaluates dsRNA removal using affinity chromatography, finding that mRNA polydispersity significantly affects dsRNA removal efficiency.
bioRxiv · Sep 23, 2026 · PreprintBiochemistry