Hector Corrada Bravo

Heterogeneity of Transcription Factor binding specificity models within and across cell lines

This study develops TRISECT, an ensemble method to identify heterogeneous TF binding rules across cell types, showing improved accuracy in predicting TF occupancy and revealing shared binding rules with functionally coherent targets.

Distinct genomic and epigenomic features demarcate hypomethylated blocks in colon cancer

The paper identifies hypomethylated blocks in colon cancer and shows they are marked by specific epigenomic and transcription factor features, including H3K4me3 and CTCF sites.

Privacy-Preserving Microbiome Analysis Using Secure Computation

The paper develops a privacy-preserving framework for microbiome analysis using secure computation to enable collaborative research without revealing individual patient data.