Co-fluctuations of genes in single cells predict transcriptome-wide outcomes to perturbations
Benjamin Kuznets-Speck, Nitu Kumari, Irish Senthilkumar, Jaekwon Jung, Hector Manuel Lopez Rios, Leon Schwartz, Hanxiao Sun, Vidyesh Rao Anisetti, Changhu Wang, Qingyang Wang, Pornchanan Pholraksa, Emanuelle I. Grody, Madeline E. Melzer, Benjamin Haley, Ekta Prashnani, , Yogesh Goyal
CIPHER uses gene co-fluctuations in unperturbed cells to predict transcriptome-wide responses to perturbations, outperforming existing methods and revealing key regulatory structures.
bioRxiv · Jun 27, 2025 · PreprintSystems Biology