Qingyang Wang

Cell-Cell-seq maps transcriptional states in interacting cell pairs by profiling defined dyads, revealing emergent gene programs and cross-cell coordination in tumor-T cell interactions.

CIPHER uses gene co-fluctuations in unperturbed cells to predict transcriptome-wide responses to perturbations, outperforming existing methods and revealing key regulatory structures.

This study identifies small-molecule ligands for TRIM21, an E3 ligase, demonstrating their ability to degrade nuclear pore complex proteins and induce cell death in cancer cells.

The paper introduces a method to quantify diverse perturbation responses and discover novel biological insights in single-cell perturbation datasets.

The paper introduces scDesign3, a statistical simulator that generates realistic single-cell and spatial omics data and infers biologically meaningful parameters for benchmarking computational tools.