A feline model of human LDLR-related atherosclerosis
Marjo K. Hytönen, Veera K. Karkamo, Sruthi Hundi, Niina Airas, Maria K. Kaukonen, Antti Sukura, Leslie A. Lyons, Heidi A Anderson, Ilona Kareinen, Hannes Lohi
The paper identifies a homozygous LDLR variant in Korat cats causing atherosclerosis, providing a model for studying human LDLR-related hypercholesterolemia and potential gene-editing therapies.
bioRxiv · Dec 4, 2024 · PreprintGenetics