Hannes Lohi

This study examines how obesity and sarcopenia alter metabolite profiles in dogs, finding increased inflammation and lipid metabolism disruptions in overweight dogs and modest metabolic effects in those with reduced muscle mass.

The paper creates a transcription-based atlas of canine regulatory elements across tissues and development, identifying promoters and enhancers and their activity patterns.

This study identifies a nonsense mutation in the PRKG2 gene as the cause of chondrodysplasia in Dalmatian dogs, resolving a long-standing genetic mystery.

The paper investigates mutation rates in 43 dog breeds, finding stable rates influenced by parental age and breed-specific differences in mutation accumulation.

This paper identifies a homozygous nonsense variant in ITPR3 in Lancashire Heeler dogs causing enamel defects and nerve dysfunction, showing IP3R3 loss affects IP3R1 and IP3R2 levels and Ca2+ signaling.

The paper identifies a homozygous LDLR variant in Korat cats causing atherosclerosis, providing a model for studying human LDLR-related hypercholesterolemia and potential gene-editing therapies.

This study uses a genotype-first approach to identify new mutations related to craniofacial morphology and stature in dogs, highlighting the role of allelic heterogeneity in breed trait selection.

This study genotypes over 11,000 domestic cats to analyze genetic variants related to blood type, disease, and traits, revealing breed-specific distributions and diversity.

The paper identifies regulatory modules controlling dog color patterns and shows their evolutionary origin in extinct canids.

The paper identifies metabolic changes in dogs with elevated blood creatinine using NMR metabolomics, finding associations with several biomarkers and suggesting potential diagnostic and therapeutic targets.

This paper develops and validates a quantitative NMR-based metabolomics platform for canine serum and plasma, defining reference intervals and demonstrating its clinical relevance.

FEELnc annotates long non-coding RNAs and mRNAs in the dog transcriptome, identifying 10,374 novel lncRNAs and 58,640 new mRNA transcripts.