Efficient parameterization of large-scale mechanistic models enables drug response prediction for cancer cell lines
Fabian Fröhlich, Thomas Kessler, Daniel Weindl, Alexey A. Shadrin, Leonard Schmiester, Hendrik Hache, Artur Muradyan, Moritz Schütte, Ji‐Hyun Lim, Matthias Heinig, Fabian Joachim Theis, Hans Rudolf Lehrach, Christoph Wierling, Bodo M. H. Lange, Jan Hasenauer
The paper presents a computational framework to parameterize large-scale mechanistic models for predicting drug response in cancer cell lines using exome and transcriptome data, achieving higher accuracy than statistical approaches.
Cell Systems · Nov 28, 2018Peer-reviewedSystems Biology