Cost-effective hybrid long- and short-read sequencing enables accurate somatic structural variant detection
Runtian Gao, Tao Jiang, Heng Hu, Zhongjun Jiang, Shuqi Cao, Murong Zhou, Yuming Zhao, Guohua Wang
This paper introduces SomaSV, a hybrid sequencing framework that improves somatic structural variant detection accuracy while reducing costs by combining long- and short-read data.
bioRxiv · Feb 17, 2026 · PreprintBioinformatics