Genetic and Epigenetic Contributors to Cleft Laterality: Evidence from Monozygotic Mirror Twins and Replication Cohorts
Aline Lourenço Petrin, Waheed A. Awotoye, Christina Spencer, Ligiane Alves Machado‐Paula, Luke Hovey, Henry Keen, Michael S. Chimenti, Patrick John Breheny, Fang Qian, Shareef M. Dabdoub, James C. Thomas, Azeez Butali, Jeffrey C. Murray, Shankar Rengasamy Venugopalan, Lina M. Moreno‐Uribe
This study identifies genetic and epigenetic factors contributing to cleft laterality using monozygotic twins and replication cohorts, finding methylation differences in ARID5B, ZFP57, and HOOK2 associated with cleft side and severity.
Human Molecular Genetics · Jan 1, 2026Peer-reviewedGenetic & Genomic Medicine