Michael S. Chimenti

PI3K regulates TAZ/YAP and mTORC1 axes that can be synergistically targeted

This study identifies PI3K-regulated TAZ/YAP and mTORC1 pathways in sarcomas and shows that targeting both synergistically reduces tumor growth.

Genetic and Epigenetic Contributors to Cleft Laterality: Evidence from Monozygotic Mirror Twins and Replication Cohorts

This study identifies genetic and epigenetic factors contributing to cleft laterality using monozygotic twins and replication cohorts, finding methylation differences in ARID5B, ZFP57, and HOOK2 associated with cleft side and severity.

EHE cell cultures: a platform for mechanistic and therapeutic investigation

The paper develops EHE primary cell cultures to study the disease's mechanisms and test therapies, finding they exhibit EHE features and respond to TEAD inhibitors.

Spatial Transcriptomics Analysis Uncovers ER stress in MANF-deficient Purkinje Cells Underlying Alcohol-induced Cerebellar Vulnerability in Mice

This study uses spatial transcriptomics to show that MANF deficiency in Purkinje cells increases ER stress and vulnerability to alcohol-induced neurodegeneration in a sex-dependent manner in mice.

Maternal α-cypermethrin and permethrin exert differential effects on fetal growth, placental morphology, and fetal neurodevelopment in mice

This study compares the effects of maternal exposure to two pyrethroid insecticides, permethrin and α-cypermethrin, on fetal growth, placental morphology, and neurodevelopment in mice, finding that α-cypermethrin has more pronounced adverse effects.

MixOmics Integration of Biological Datasets Identifies Highly Correlated Key Variables of COVID-19 severity.

The paper integrates proteomic and transcriptomic data from a small cohort of COVID-19 patients to identify key variables correlated with disease severity.

Development of a humanized anti-FABP4 monoclonal antibody for treatment of breast cancer

This paper develops humanized anti-FABP4 monoclonal antibodies that inhibit breast cancer tumor growth and metastasis by targeting FABP4's role in lipid metabolism.

Whole genome sequencing of a family with autosomal dominant features within the oculoauriculovertebral spectrum

The paper identifies rare mutations in SIX1, PDGFRA, and KDR/VEGFR2 associated with OAVS phenotypes through whole genome sequencing and statistical analysis of a family.

Learning induces unique transcriptional landscapes in the auditory cortex

The paper identifies genome-wide gene expression changes in the auditory cortex of rats during learning, highlighting pathways involved in long-term auditory memory formation.

Selective neuroimmune modulation by type I interferon drives neuropathology and neurologic dysfunction following traumatic brain injury

This study shows that type I interferon signaling worsens neuropathology and neurologic dysfunction after traumatic brain injury by modulating neuroimmune responses.

Lateral Septal Circuits Govern Schizophrenia-Like Effects of Ketamine on Social Behavior

This study identifies the lateral septum as a key circuit involved in ketamine-induced social deficits, showing that its hypoactivation contributes to schizophrenia-like behaviors.

Transcriptome profiles in brains of mice heterozygous for a DYT1 dystonia-associated mutation in the endogenous Tor1a gene

The paper examines transcriptome profiles in mouse brain regions with a DYT1 dystonia mutation, finding subtle genotype-dependent changes across regions but not within individual regions.