A UVB-responsive common variant at chr7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor gene (AHR)
Mai Xu, Lindsey Catherine Mehl, Tongwu Zhang, Rohit Thakur, Hayley Sowards, Timothy A. Myers, Lea Jessop, Alessandra Chesi, Matthew E. Johnson, Andrew D. Wells, Helen T. Michael, Patricia Bunda, Kristine M. Jones, Herbert Higson, Rebecca C. Hennessey, , Kevin M. Brown
This paper identifies rs117132860 as a functional variant at 7p21.1 that regulates AHR expression in response to UVB, contributing to melanoma risk and tanning ability.
The American Journal of Human Genetics · Aug 2, 2021Peer-reviewedGenetics