Author

Lea Jessop

National Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Genetic & Genomic Medicine· 2 Genetics· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:fine-mapping· 3 Research Focus:gene regulatory network inference· 2 Assay:GWAS summary statistics· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Jiyeon ChoiiD· 4 shared Mai XuiD· 4 shared Rohit ThakuriD· 4 shared Tongwu ZhangiD· 4 shared Hayley SowardsiD· 3 shared Joshuah YoniD· 3 shared Kevin M. BrowniD· 3 shared Maria Teresa LandiiD· 3 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetic & Genomic Medicine

Jiyeon ChoiORCID

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4 papers

Recent·Most cited

Melanoma germline genetics: immune, cancer driver, and Wnt signaling genes

G J M Shanika R Jayasinghe, Jianxin Shi, Rohit Thakur, Rebecca Ivy Hartman, Huanwei Wang, Phuc H. Hoang, Daniel R. Dochtermann, Samuel Anyaso-Samuel, Mathias Seviiri, Quan Hoang Nguyen, P. Prakrithi, Thi-Van-Trinh Tran, Xiaoyu Wang, Mai Xu, Xing Hua, , Nhan Do

This paper identifies 116 risk loci for melanoma through GWAS, links susceptibility to immunity and Wnt signaling, and develops a PRS improving risk prediction.

medRxiv · Oct 15, 2026 · PreprintGenetic & Genomic Medicine

Functional characterization of the 9q34.13 locus identifies RAPGEF1 as modulating risk for melanoma and nevi via RAS activation

Rohit Thakur, Mai Xu, Alexandra M. Thornock, Joshuah Yon, Samuel Anyaso-Samuel, Martin Lauss, Thomas Rehling, Linh T. Bui, Hayley Sowards, Gerard Duncan, Lea Jessop, Timothy Myers, Raj Chari, Erping Long, Karen M. Funderburk, , Kevin M. Brown

This study identifies RAPGEF1 as a gene modulating melanoma and nevi risk through RAS activation, using fine-mapping, expression data, and functional assays.

bioRxiv · Feb 9, 2026 · PreprintGenetics

Mapping chromatin interactions at melanoma susceptibility loci and cell-type specific dataset integration uncovers distant gene targets of cis-regulation

Rohit Thakur, Mai Xu, Hayley Sowards, Joshuah Yon, Lea Jessop, Timothy Myers, Tongwu Zhang, Raj Chari, Erping Long, Thomas Rehling, Rebecca C. Hennessey, Karen M. Funderburk, Jinhu Yin, Mitchell J. Machiela, Matthew E. Johnson, , Kevin M. Brown

The paper identifies candidate causal variants and genes at melanoma risk loci using capture-HiC and integrates multi-omics data to prioritize cis-regulatory interactions.

medRxiv · Nov 14, 2024 · PreprintGenetic & Genomic Medicine

A UVB-responsive common variant at chr7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor gene (AHR)

Mai Xu, Lindsey Catherine Mehl, Tongwu Zhang, Rohit Thakur, Hayley Sowards, Timothy A. Myers, Lea Jessop, Alessandra Chesi, Matthew E. Johnson, Andrew D. Wells, Helen T. Michael, Patricia Bunda, Kristine M. Jones, Herbert Higson, Rebecca C. Hennessey, , Kevin M. Brown

This paper identifies rs117132860 as a functional variant at 7p21.1 that regulates AHR expression in response to UVB, contributing to melanoma risk and tanning ability.

The American Journal of Human Genetics · Aug 2, 2021Peer-reviewedGenetics