Itaconate utilisation by the human pathogen Pseudomonas aeruginosa requires uptake via the IctPQM TRAP transporter
Javeria Mehboob, Reyme Herman, Rory Elston, Heritage Afolabi, Bethan E. Kinniment-Williams, Marjan W. van der Woude, Anthony J. Wilkinson, Gavin H. Thomas
This study identifies the IctPQM TRAP transporter as essential for Pseudomonas aeruginosa to utilize itaconate, a host-derived metabolite, by showing its specific binding and structural adaptations.
Biochemical Journal · Aug 28, 2025Peer-reviewedMicrobiology