TFE3 fusion proteins drive oxidative metabolism, ferroptosis resistance and general RNA synthesis in translocation renal cell carcinoma
Alexandra Helleux, Guillaume Davidson, Antonin Lallement, Fatima Al Hourani, Alexandre R. Haller, Isabelle Michel, Anas Fadloun, Christelle Thibault-Carpentier, Xiaoping Su, Véronique Lindner, Thibault Tricard, Hervé Lang, Nizar M. Tannir, Irwin Davidson, Gabriel G. Malouf
This study identifies how TFE3 fusion proteins drive oxidative metabolism, ferroptosis resistance, and RNA synthesis in translocation renal cell carcinoma through genome-wide binding and multi-omics analyses.
EMBO Molecular Medicine · Mar 27, 2025Peer-reviewedCancer Biology