Same class, different activity: Delamanid and pretomanid have comparable bactericidal activity but pretomanid potently inhibits Mycobacterium tuberculosis ribosomal rRNA synthesis
Matthew J. Reichlen, Emmanuel Musisi, Samuel T. Tabor, Holly Nielson, Ashley M Gerwing, Firat Kaya, Matthew D. Zimmerman, Martin I. Voskuil, Gregory T. Robertson, Nicholas D. Walter
This study compares delamanid and pretomanid, finding similar bactericidal activity but pretomanid more effectively inhibits M. tuberculosis ribosomal rRNA synthesis.
bioRxiv · Dec 30, 2025 · PreprintMicrobiology