XAMP: debiased dual-engine AI framework enables global discovery of antimicrobial peptides from deep-sea microbiomes
Bairun Chen, Xinyi Mou, Zhuoxuan Song, Huaying Lin, Tianyi Han, Runze Wang, Hong-Yu Ou, Yu Zhang, Jing Li
XAMP improves antimicrobial peptide discovery by addressing data biases, identifying 2,355 candidates from deep-sea metagenomes, and validating six peptides with broad-spectrum activity against drug-resistant pathogens.
bioRxiv · Nov 20, 2025 · PreprintBioinformatics