Nuclear Receptor Liver Receptor Homolog-1 drives Intestinal Stem Cell regeneration and UPR/ER stress response after gut injury
Hsi-Ju Chen, Kristina N. Braverman, Bohan Yu, James R. Bayrer
This study identifies LRH-1 as essential for intestinal stem cell regeneration and ER stress response after gut injury, revealing its role in sustaining the IRE1-XBP1 UPR pathway.
bioRxiv · May 18, 2026 · PreprintCell Biology