A computational framework for designing micron-scale crisscross DNA megastructures
Matthew Aquilina, Florian Katzmeier, Minke A. D. Nijenhuis, Siyuan S. Wang, Corey Becker, Yichen Zhao, Su Hyun Seok, Julie Finkel, Huangchen Cui, J H Lee, Seungwoo Lee, William M. Shih
This paper develops a computational framework to design crisscross DNA megastructures, optimizing handle assignment and expanding handle libraries to enable large-scale fabrication.
Nature Communications · Jul 17, 2026Peer-reviewedSynthetic Biology