Improved Accuracy for Modeling PROTAC-Mediated Ternary Complex Formation and Targeted Protein Degradation via New In Silico Methodologies
Michael L Drummond, Andrew Henry, Huifang Li, Christopher I Williams
This paper introduces two new computational methods to model PROTAC-mediated ternary complex formation and predict protein degradation efficacy, showing high accuracy in both known and unknown structures.
bioRxiv · Jul 10, 2020Biochemistry