The vP300 Framework: Trial-to-Trial Variability in the P300 Event-Related Potential as a Signal of Locus Coeruleus-Norepinephrine Dynamics
Jianhua Su, Huilin Hu, Xin Su, Yannan Huang
The paper introduces the vP300 framework, showing that P300 trial-to-trial variability, measured by coefficient of variation, reflects LC-NE dynamics and predicts cognitive flexibility better than mean amplitude.
bioRxiv · Aug 5, 2026 · PreprintPhysiology