Targeting PI3Kβ-dependent cancer with a novel small molecule inhibitor, GT220
Qi Wang, Huimin Cheng, Xiangyang Yu, Changli Qian, Renlei Ji, Thomas M. Roberts, William Kerns, Jean J. Zhao
This paper develops GT220, a selective PI3Kβ inhibitor, showing efficacy in PTEN-deficient cancers while sparing normal cells.
bioRxiv · Feb 25, 2026 · PreprintCancer Biology