Biophysical Modeling Uncovers Transcription Factor and Nucleosome Binding on Single DNA Molecules
Lasha Dalakishvili, Husain Managori, Anaïs F. Bardet, Věra Slaninová, Édouard Bertrand, Nacho Molina
The paper introduces HiddenFoot, a probabilistic model to infer TF, nucleosome, and Pol II occupancy from single-molecule data, revealing binding dynamics and heterogeneity in mouse, Drosophila, and human cells.
bioRxiv · May 13, 2025 · PreprintGenomics