Whole-brain protein profiling using organ-scale multiplexed immunolabeling and image co-registration
Sehun Kim, Hyeongryool Park, Wonjin Cho, Sangbin Yoo, Thananya Charoenpattarawut, Christopher E. Pearson, Young-Gyun Park
This paper introduces 3D CYCLIC and TACTIC to enable organ-scale multiplexed protein imaging and co-registration, allowing comprehensive analysis of whole-brain protein profiles.
bioRxiv · May 18, 2026 · PreprintNeuroscience