I. Derenyi

How plants minimize somatic evolution

This paper shows plants minimize mutation accumulation by optimizing cell division patterns in apical buds to approach a theoretical minimum branching cost.

Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization

The paper shows that a trade-off between mutation accumulation and differentiation commitment shapes tissue organization to limit cancer risk.

Cancer Risk and the Somatic Cell Lineage Tree

This paper analyzes how the structure of cell lineage trees influences cancer risk by deriving an analytical formula that links lineage length distributions to mutation accumulation probabilities.

A compartment size dependent selective threshold limits mutation accumulation in hierarchical tissues

This paper shows that small tissue compartments create a selective threshold that prevents mutations with proliferative advantages from persisting, thereby slowing somatic evolution and reducing cancer risk.

Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations

The paper develops a model showing hierarchical tissue organization limits somatic mutation accumulation by reducing divisional load, independent of differentiation processes.