Recurrent mobilization of ancestral and novel variants of the chromosomal di-hydrofolate reductase gene drives the emergence of clinical resistance to trimethoprim
M. Sanchez-Osuna, P. Cortes, M. Llagostera, J. Barbe, I. Erill
This paper identifies recurrent mobilization of ancestral and novel dfrA genes contributing to trimethoprim resistance, showing resistance predated clinical use.
Microbial Genomics · Nov 1, 2020Peer-reviewedMicrobiology