Nano-scale viscometry reveals an inherent mucus defect in cystic fibrosis
O. Ponomarchuk, F. Boudreault, I. Gryczynski, S. V. Dzyuba, R. Fudala, Z. Gryczynski, J. W. Hanrahan, R. Grygorczyk
This study uses nano-scale viscometry to show elevated mucin nanoviscosity in CF mucin granules, indicating a pre-secretory defect and challenging the classical model of mucus structure.
bioRxiv · Mar 6, 2024 · PreprintCell Biology