Structural dynamics of E6AP E3 ligase HECT domain and involvement of flexible hinge loop in ubiquitin chain synthesis mechanism
H. Konno, K. Takeda, I. Muro, F. Kobayashi, H. Flechsig, N. Kodera, T. Ando
This study uses high-speed atomic force microscopy to demonstrate the structural dynamics of the E6AP HECT domain and shows how hinge loop flexibility affects Ub chain formation.
bioRxiv · Nov 18, 2022Biophysics