Spontaneous human CD8 T cell and EAE-inducible human CD4/CD8 T cell lesions in the brain and spinal cord of HLA-DRB1*15-positive multiple sclerosis PBMC humanized mice
I. Papazian, M. Kourouvani, A. Dagkonaki, V. Gouzouasis, L. Dimitrakopoulou, N. Markoglou, F. Badounas, T. Tselios, M. Anagnostouli, L. Probert
This study develops a humanized mouse model of multiple sclerosis using PBMCs from HLA-DRB1*15-positive patients, showing spontaneous and EAE-induced T cell lesions in CNS tissues.
bioRxiv · Jun 7, 2023Immunology