Design of Novel Selective Serotonin Reuptake Inhibitors Using Computational Modeling Studies
L. E. H. Svanholm, I. S. Torrence, T. Q. Nguyen, J. B. Siegel
This study uses computational modeling to design two novel SSRIs with higher binding affinity to hSERT than existing drugs and identifies Macaca fascicularis as a suitable preclinical model.
bioRxiv · Oct 10, 2022 · PreprintPharmacology & Toxicology