Analysis of the PcrA-RNA polymerase complex reveals a helicase interaction motif and a role for PcrA/UvrD helicase in the suppression of R-loops.
I. Urrutia, J. Ault, F. Sobott, N. Savery, M. S. Dillingham
This study identifies a helicase interaction motif in the PcrA-RNAP complex and shows PcrA's role in suppressing R-loops by resolving transcription-replication conflicts.
bioRxiv · Mar 15, 2021Biochemistry